Coq8b Gene Summary [Mouse]
Predicted to enable protein kinase activity. Predicted to be involved in cerebellar Purkinje cell layer morphogenesis and ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and spinal cord. Human ortholog(s) of this gene implicated in nephrotic syndrome type 9. Orthologous to human COQ8B (coenzyme Q8B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Coq8b |
| Official Name | coenzyme Q8B [Source:MGI Symbol;Acc:MGI:1924139] |
| Ensembl ID | ENSMUSG00000003762 |
| Bio databases IDs | |
| Aliases | coenzyme Q8B |
| Synonyms | 0610012P18RIK, ADCK4, coenzyme Q8B, NPHS9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Coq8b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein kinase
- lipid binding
- Protein Kinases, catalytic domain
- ABC1 atypical kinase-like domain
- ATPase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Kawasaki disease
- chronic obstructive pulmonary disease
- nephrotic syndrome type 9
- retinitis pigmentosa
- hereditary disorder
- ulcerative colitis
- nicotine dependence
- nephrosis
- inflammatory bowel disease
- Crohn disease
regulated by
- dexamethasone
- levodopa
- NR3C1
regulates
- ubiquinone
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Coq8b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cerebellar Purkinje cell layer morphogenesis
- protein phosphorylation
- ubiquinone biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- mitochondrion
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- lipid binding
- protein kinase activity