Kif20a Gene Summary [Mouse]
Predicted to enable several functions, including ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in several processes, including microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Predicted to be located in several cellular components, including intercellular bridge; midbody; and spindle. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm; microtubule; and nucleus. Is expressed in 4-cell stage embryo; brain; genitourinary system; and stomach. Human ortholog(s) of this gene implicated in familial restrictive cardiomyopathy 6. Orthologous to human KIF20A (kinesin family member 20A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kif20a |
| Official Name | kinesin family member 20A [Source:MGI Symbol;Acc:MGI:1201682] |
| Ensembl ID | ENSMUSG00000003779 |
| Bio databases IDs | |
| Aliases | kinesin family member 20A |
| Synonyms | kinesin family member 20A, MKLP2, RAB6KIFL, RABKINESIN 6, RCM6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kif20a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- Kinesin motor, catalytic domain
- microtubule binding
- protein kinase binding
- Myosin and Kinesin motor domain
- Kinesin motor domain
- Rab6A binding domain
- protein binding
- Knl1 RWD C-terminal domain
- RBD_KIF20A-like
Pathways
Biological processes and signaling networks where the Kif20a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- head and neck squamous cell carcinoma
- HER2 negative hormone receptor negative breast cancer
- familial restrictive cardiomyopathy type 6
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- organismal death
- diffuse large B-cell lymphoma
- head and neck squamous cell cancer
role in cell
- phosphorylation in
- proliferation
- formation
- apoptosis
- growth
- morphology
- senescence
- clustering
- cytokinesis
- cell proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- spindle apparatus
- Nucleus
- centrosome
- Golgi Apparatus
- microtubules
- midbody
- cell-cell contacts
- cytoplasmic bridges
- nucleoplasm
- cleavage furrow
- central spindle
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kif20a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule bundle formation
- cytokinesis after mitosis
- protein transport
- regulation of cytokinesis
- microtubule-based movement
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- spindle
- kinesin complex
- Golgi apparatus
- midbody
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein kinase binding
- microtubule motor activity
- protein binding
- microtubule binding