Myl9 Gene Summary [Mouse]

Enables myosin heavy chain binding activity. Predicted to be involved in myofibril assembly. Located in Z disc and stress fiber. Part of myosin II complex. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and lung. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and megacystis-microcolon-intestinal hypoperistalsis syndrome. Orthologous to human MYL9 (myosin light chain 9). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Myl9
Official Name
myosin, light polypeptide 9, regulatory [Source:MGI Symbol;Acc:MGI:2138915]
Ensembl ID
ENSMUSG00000067818
Bio databases IDs NCBI: 98932 Ensembl: ENSMUSG00000067818
Aliases myosin, light polypeptide 9, regulatory
Synonyms LC20, MLC2, Mlc20, MLC-2C, Mlc-c, MMIHS4, MRLC1, Mylc2c, myosin light chain 9, myosin, light polypeptide 9, regulatory, MYOSIN REGULATORY LIGHT CHAIN 2, SMOOTH MUSCLE isoform, MYRL2, RLC, RLC-C
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myl9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • myosin binding
  • EF-hand, calcium binding motif
  • EF-hand domain
  • structural constituent of muscle
  • structural constituent of cytoskeleton
  • EF-hand domain pair
  • EF hand
  • EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
  • EFh
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • non-insulin-dependent diabetes mellitus
  • familial platelet disorder with predisposition to acute myelogenous leukemia
  • urothelial bladder carcinoma
  • lung adenocarcinoma
  • prostate cancer
  • epithelial cancer
  • lung squamous cell carcinoma
  • transitional cell bladder cancer
  • gastric cancer
  • endometrial cancer
regulated by
regulates
role in cell
  • expression in
  • growth
  • quantity
  • migration
  • phosphorylation in
  • epithelial-mesenchymal transition
  • aggregation
  • formation
  • invasion by
  • organization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cilia
  • apical compartment
  • Mitochondria
  • contractile rings
  • cytosol
  • myosin stress fibers
  • Z line
  • actin stress fibers

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Myl9 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • myofibril assembly
  • regulation of muscle contraction
  • platelet aggregation

Cellular Component

Where in the cell the gene product is active
  • Z disc
  • muscle myosin complex
  • cytoplasm
  • cell cortex
  • stress fiber
  • cytosol
  • myofibril

Molecular Function

What the gene product does at the molecular level
  • structural constituent of muscle
  • calcium ion binding
  • myosin heavy chain binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.