Ylpm1 Gene Summary [Mouse]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of telomere maintenance. Located in nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and immune system. Orthologous to human YLPM1 (YLP motif containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ylpm1 |
| Official Name | YLP motif containing 1 [Source:MGI Symbol;Acc:MGI:1926195] |
| Ensembl ID | ENSMUSG00000021244 |
| Bio databases IDs | |
| Aliases | YLP motif containing 1 |
| Synonyms | A930013E17Rik, AI851834, C14orf170, Nuclear protein ZAP3, PPP1R169, RGD1564946, YLP motif containing 1, ZAP, ZAP113, ZAP3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ylpm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- major depression
- acute myeloid leukemia
- neuroticism
- neurotic disorder
- type I enteropathy-associated T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- gastroesophageal reflux
- anxiety disorder
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ylpm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding