Ddx46 Gene Summary [Mouse]
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in U2-type prespliceosome assembly. Predicted to be located in fibrillar center and nuclear speck. Predicted to be part of U2-type spliceosomal complex. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer. Orthologous to human DDX46 (DEAD-box helicase 46). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ddx46 |
| Official Name | DEAD box helicase 46 [Source:MGI Symbol;Acc:MGI:1920895] |
| Ensembl ID | ENSMUSG00000021500 |
| Bio databases IDs | |
| Aliases | DEAD box helicase 46 |
| Synonyms | 2200005K02Rik, 8430438J23RIK, AI957095, DEAD-box helicase 46, KIAA0801, LOC245957, mKIAA0801, Prp5, PRPF5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ddx46 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- K homology (KH) RNA-binding domain, type I
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- N-terminal helicase domain of the DEAD-box helicase superfamily
- enzyme
- protein binding
- DEAD-like helicases superfamily
- Helicase conserved C-terminal domain
- RNA helicase
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
- nuclear speckles
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ddx46 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- Cajal body
- spliceosomal complex
- U2-type spliceosomal complex
- U2 snRNP
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA binding
- RNA helicase activity