Atp6v1f Gene Summary [Mouse]
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in synaptic vesicle lumen acidification. Part of proton-transporting V-type ATPase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human ATP6V1F (ATPase H+ transporting V1 subunit F). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v1f |
| Official Name | ATPase, H+ transporting, lysosomal V1 subunit F [Source:MGI Symbol;Acc:MGI:1913394] |
| Ensembl ID | ENSMUSG00000004285 |
| Bio databases IDs | |
| Aliases | ATPase, H+ transporting, lysosomal V1 subunit F |
| Synonyms | 1110004G16Rik, ATP6S14, ATPase, H+ transporting, lysosomal V1 subunit F, ATPase H+ transporting V1 subunit F, Vacuolar ATPase Subunit 1F, Vacuolar ATP Synthase Subunit F, VATF, V-ATPase V1-F, Vma7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp6v1f often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP synthase (F/14-kDa) subunit
- H+-transporting two-sector ATPase
- enzyme
- protein binding
- PRK03957
Pathways
Biological processes and signaling networks where the Atp6v1f gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal adenoma
- colorectal adenoma formation
- Alzheimer disease
regulates
- TF
role in cell
- morphology
- Clathrin mediated endocytosis by
- acidification in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp6v1f gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular pH reduction
- endosomal lumen acidification
- lysosomal lumen acidification
- vacuolar acidification
Cellular Component
Where in the cell the gene product is active
- proton-transporting V-type ATPase complex
- Golgi membrane
- plasma membrane
- lysosomal membrane
- vacuolar proton-transporting V-type ATPase, V1 domain
- extracellular vesicular exosome
- membrane
- vacuolar proton-transporting V-type ATPase complex
- cytosol
- endosome membrane
- synaptic vesicle membrane
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity, coupled to transmembrane movement of ions
- protein binding
- hydrogen ion transmembrane transporter activity
- proton-transporting ATPase activity, rotational mechanism