Plxdc2 Gene Summary [Mouse]
Located in collagen-containing extracellular matrix. Is expressed in several structures, including central nervous system; inner ear; limb; skin; and trunk mesenchyme. Orthologous to human PLXDC2 (plexin domain containing 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plxdc2 |
| Official Name | plexin domain containing 2 [Source:MGI Symbol;Acc:MGI:1914698] |
| Ensembl ID | ENSMUSG00000026748 |
| Bio databases IDs | |
| Aliases | plexin domain containing 2 |
| Synonyms | 1200007L24Rik, 5430431D22RIK, Kst37, LOC108348594, plexin domain containing 2, PLXDC2-OT, TEM7R |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plxdc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Plexin repeat
- ectodomain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- endometriosis
- bronchopulmonary dysplasia
- retinal detachment
- acute myeloid leukemia
- diabetic retinopathy
- chronic kidney disease
- proteinuria
role in cell
- activation in
- expression in
- invasion by
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plxdc2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding