Gpx5 Gene Summary [Mouse]
Predicted to enable glutathione peroxidase activity. Acts upstream of or within cellular response to oxidative stress. Located in extracellular space and sperm plasma membrane. Is expressed in several structures, including male reproductive gland or organ and placenta. Orthologous to human GPX5 (glutathione peroxidase 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpx5 |
| Official Name | glutathione peroxidase 5 [Source:MGI Symbol;Acc:MGI:104886] |
| Ensembl ID | ENSMUSG00000004344 |
| Bio databases IDs | |
| Aliases | glutathione peroxidase 5 |
| Synonyms | Arep, EGLP, epididymal androgen-related, glutathione peroxidase 5, GSHPx-5, HEL-S-75p, LOC100360928 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpx5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- glutathione peroxidase
Pathways
Biological processes and signaling networks where the Gpx5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpx5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid metabolic process
- cellular response to oxidative stress
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- glutathione peroxidase activity