Tmx1 Gene Summary [Mouse]
Enables protein disulfide isomerase activity. Involved in negative regulation of platelet aggregation. Predicted to be located in extracellular region and mitochondrial membrane. Predicted to be active in endoplasmic reticulum membrane and mitochondria-associated endoplasmic reticulum membrane contact site. Orthologous to human TMX1 (thioredoxin related transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmx1 |
| Official Name | thioredoxin-related transmembrane protein 1 [Source:MGI Symbol;Acc:MGI:1919986] |
| Ensembl ID | ENSMUSG00000021072 |
| Bio databases IDs | |
| Aliases | thioredoxin-related transmembrane protein 1 |
| Synonyms | 2810425A04Rik, PDIA11, thioredoxin-related transmembrane protein 1, TMX, TXNDC, TXNDC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein disulfide-isomerase
- disulfide oxidoreductase
- thioredoxin-like domain
- protein disulfide oxidoreductase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme inhibitor activity
- enzyme
- protein binding
- thioredoxin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- preeclampsia
- intoxication
regulates
- Ca2+
- triacylglycerol
- adenosine triphosphate
- HLA-B
- Ricin
- INS
- Abrin
role in cell
- apoptosis
- interaction in
- clearance in
- interaction
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- plasma membrane fraction
- pH resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of triglyceride biosynthetic process
- negative regulation of platelet aggregation
- regulation of calcium ion transport
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- mitochondrial membrane
- ER-mitochondrion membrane contact site
- endomembrane system
- extracellular region
Molecular Function
What the gene product does at the molecular level
- disulfide oxidoreductase activity
- protein binding
- protein disulfide isomerase activity
- protein disulfide oxidoreductase activity
- enzyme inhibitor activity