Sgtb Gene Summary [Mouse]
Predicted to enable Hsp70 protein binding activity; molecular adaptor activity; and protein dimerization activity. Predicted to be involved in post-translational protein targeting to endoplasmic reticulum membrane; protein heterooligomerization; and protein homooligomerization. Predicted to be part of TRC complex. Predicted to be active in membrane. Is expressed in nervous system and sensory organ. Orthologous to human SGTB (small glutamine rich tetratricopeptide repeat co-chaperone beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sgtb |
| Official Name | small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta [Source:MGI Symbol;Acc:MGI:2444615] |
| Ensembl ID | ENSMUSG00000042743 |
| Bio databases IDs | |
| Aliases | small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta |
| Synonyms | C630001O05Rik, SGT2, small glutamine rich tetratricopeptide repeat co-chaperone beta, small glutamine rich tetratricopeptide repeat co-chaperone β, small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta, small glutamine-rich tetratricopeptide repeat (TPR)-containing, β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sgtb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hsp70 protein binding
- TPR repeat
- Tetratricopeptide repeats
- Homodimerization domain of SGTA
- protein homodimerization
- protein binding
- chaperone binding
- tetratricopeptide repeat
- identical protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sgtb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homooligomerization
- protein heterooligomerization
- posttranslational protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- membrane
- TRC complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- Hsp70 protein binding
- binding, bridging