Men1 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity; chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in transcription initiation-coupled chromatin remodeling. Acts upstream of or within several processes, including negative regulation of cell population proliferation; regulation of osteoblast differentiation; and regulation of transcription by RNA polymerase II. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; gonad; and sensory organ. Used to study growth hormone secreting pituitary adenoma; hyperparathyroidism; multiple endocrine neoplasia type 1; and prolactinoma. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Men1 |
| Official Name | multiple endocrine neoplasia 1 [Source:MGI Symbol;Acc:MGI:1316736] |
| Ensembl ID | ENSMUSG00000024947 |
| Bio databases IDs | |
| Aliases | multiple endocrine neoplasia 1 |
| Synonyms | MEAI, MENIN, menin 1, multiple endocrine neoplasia 1, SCG2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Men1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- transcription regulator
- LXXLL motif
- nucleic acid binding
- Sin3 binding domain
- DNA secondary structure binding
- protein binding activity, bridging
- nuclear localization sequence
- phosphoprotein binding
- Menin
- central domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- msin3a protein-binding domain
- double-stranded DNA binding
- Scaffolding protein menin encoded by the MEN1 gene
- JunD interaction domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- multiple endocrine neoplasia type 1
- hypoplasia
- hereditary cancer-predisposing syndrome
- neoplasia
- head and neck neoplasia
- neuroendocrine carcinoma
- neuroendocrine cancer
- epithelial cancer
- gastrointestinal neoplasia
role in cell
- expression in
- migration
- differentiation
- cell death
- multinucleation in
- growth
- phosphorylation in
- proliferation
- apoptosis
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- nuclear matrix fraction
- membrane fraction
- Cytoplasm
- perinuclear region
- microtubules
- cytosol
- endoplasmic reticulum lumen
- nucleoplasm
- nuclear bodies
- spindle pole
- nuclear matrix
- cleavage furrow
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Men1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- positive regulation of gene expression, epigenetic
- negative regulation of cell proliferation
- negative regulation of cell cycle
- response to UV
- negative regulation of sequence-specific DNA binding transcription factor activity
- osteoblast development
- response to DNA damage stimulus
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of JNK cascade
- negative regulation of cyclin-dependent protein kinase activity
- regulation of transcription from RNA polymerase II promoter
- negative regulation of osteoblast differentiation
- negative regulation of transcription from RNA polymerase II promoter
- T-helper 2 cell differentiation
- MAPK cascade
- negative regulation of transcription, DNA-dependent
- negative regulation of protein phosphorylation
- response to gamma radiation
- negative regulation of telomerase activity
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cleavage furrow
- histone methyltransferase complex
- chromatin
- nucleoplasm
- chromosome, telomeric region
- endoplasmic reticulum lumen
- nucleus
- cytoplasm
- transcriptional repressor complex
- cytosol
- nuclear matrix
- macromolecular complex
- MLL1 complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- R-SMAD binding
- double-stranded DNA binding
- transcription regulatory region sequence-specific DNA binding
- phosphoprotein binding
- Y-form DNA binding
- chromatin binding
- protein binding, bridging
- four-way junction DNA binding