Men1 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity; chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in transcription initiation-coupled chromatin remodeling. Acts upstream of or within several processes, including negative regulation of cell population proliferation; regulation of osteoblast differentiation; and regulation of transcription by RNA polymerase II. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; gonad; and sensory organ. Used to study growth hormone secreting pituitary adenoma; hyperparathyroidism; multiple endocrine neoplasia type 1; and prolactinoma. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Men1 |
| Official Name | multiple endocrine neoplasia 1 [Source:MGI Symbol;Acc:MGI:1316736] |
| Ensembl ID | ENSMUSG00000024947 |
| Bio databases IDs | |
| Aliases | multiple endocrine neoplasia 1 |
| Synonyms | MEAI, MENIN, menin 1, multiple endocrine neoplasia 1, SCG2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Men1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- transcription regulator
- LXXLL motif
- nucleic acid binding
- Sin3 binding domain
- DNA secondary structure binding
- protein binding activity, bridging
- nuclear localization sequence
- phosphoprotein binding
- Menin
- central domain
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- msin3a protein-binding domain
- double-stranded DNA binding
- Scaffolding protein menin encoded by the MEN1 gene
- JunD interaction domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- multiple endocrine neoplasia type 1
- hypoplasia
- hereditary cancer-predisposing syndrome
- neoplasia
- head and neck neoplasia
- neuroendocrine carcinoma
- neuroendocrine cancer
- epithelial cancer
- gastrointestinal neoplasia
phenotypes
- Leydig cell hyperplasia
- abnormal cell differentiation
- abnormal craniofacial development
- abnormal embryonic tissue morphology
- abnormal neural tube closure
- abnormal pancreas morphology
- abnormal pancreatic acinar cell morphology
- abnormal pituitary gland morphology
- decreased circulating phosphate level
- decreased embryo size
- delayed hepatic development
- embryonic growth retardation
- embryonic lethality during organogenesis complete penetrance
- embryonic lethality complete penetrance
- enlarged adrenal glands
- enlarged ovary
- enlarged pituitary gland
- enlarged testis
- exencephaly
- hemorrhage
- hypoglycemia
- increased Leydig cell tumor incidence
- increased adrenal cortical tumor incidence
- increased adrenal gland adenoma incidence
- increased adrenal gland tumor incidence
- increased adrenocortical adenoma incidence
- increased carcinoma incidence
- increased circulating calcium level
- increased circulating corticosterone level
- increased circulating insulin level
- increased gastrointestinal tumor incidence
- increased gland tumor incidence
- increased glucagonoma incidence
- increased gonad tumor incidence
- increased insulinoma incidence
- increased intestinal adenoma incidence
- increased lung adenocarcinoma incidence
- increased lung tumor incidence
- increased mammary gland tumor incidence
- increased ovary tumor incidence
- increased pancreas adenoma incidence
- increased pancreas tumor incidence
- increased pancreatic beta cell number
- increased pancreatic islet cell adenoma incidence
- increased pancreatic islet cell carcinoma incidence
- increased parathyroid adenoma incidence
- increased parathyroid gland tumor incidence
- increased pheochromocytoma incidence
- increased pituitary adenohypophysis tumor incidence
- increased pituitary adenoma incidence
- increased pituitary gland tumor incidence
- increased prolactinoma incidence
- increased stomach tumor incidence
- increased testis tumor incidence
- increased thyroid adenoma incidence
- increased thyroid carcinoma incidence
- increased thyroid tumor incidence
- increased tumor incidence
- lethality throughout fetal growth and development complete penetrance
- pancreas cysts
- pancreas inflammation
- pancreas necrosis
- pancreatic islet hyperplasia
- parathyroid gland hyperplasia
- premature death
- thin interventricular septum
- thin ventricular wall
- thyroid gland cyst
- thyroid gland hyperplasia
- trabecula carnea hypoplasia
role in cell
- expression in
- migration
- differentiation
- cell death
- multinucleation in
- growth
- phosphorylation in
- proliferation
- apoptosis
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- nuclear matrix fraction
- membrane fraction
- Cytoplasm
- perinuclear region
- microtubules
- cytosol
- endoplasmic reticulum lumen
- nucleoplasm
- nuclear bodies
- spindle pole
- nuclear matrix
- cleavage furrow
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Men1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- positive regulation of gene expression, epigenetic
- negative regulation of cell proliferation
- negative regulation of cell cycle
- response to UV
- negative regulation of sequence-specific DNA binding transcription factor activity
- osteoblast development
- response to DNA damage stimulus
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of JNK cascade
- negative regulation of cyclin-dependent protein kinase activity
- regulation of transcription from RNA polymerase II promoter
- negative regulation of osteoblast differentiation
- negative regulation of transcription from RNA polymerase II promoter
- T-helper 2 cell differentiation
- MAPK cascade
- negative regulation of transcription, DNA-dependent
- negative regulation of protein phosphorylation
- response to gamma radiation
- negative regulation of telomerase activity
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cleavage furrow
- histone methyltransferase complex
- chromatin
- nucleoplasm
- chromosome, telomeric region
- endoplasmic reticulum lumen
- nucleus
- cytoplasm
- transcriptional repressor complex
- cytosol
- nuclear matrix
- macromolecular complex
- MLL1 complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- R-SMAD binding
- double-stranded DNA binding
- transcription regulatory region sequence-specific DNA binding
- phosphoprotein binding
- Y-form DNA binding
- chromatin binding
- protein binding, bridging
- four-way junction DNA binding