Syt6 Gene Summary [Mouse]
Enables calcium-dependent protein binding activity; phospholipid binding activity; and protein dimerization activity. Involved in acrosome reaction. Located in cytoplasmic side of plasma membrane; cytosol; and perinuclear endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human SYT6 (synaptotagmin 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syt6 |
| Official Name | synaptotagmin VI [Source:MGI Symbol;Acc:MGI:1859544] |
| Ensembl ID | ENSMUSG00000027849 |
| Bio databases IDs | |
| Aliases | synaptotagmin VI |
| Synonyms | 3110037A08RIK, AW048930, synaptotagmin 6, synaptotagmin VI, sytVI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Syt6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- calcium-dependent protein binding
- calcium-dependent phospholipid binding
- clathrin binding
- protein binding
- identical protein binding
- C2 domain (from adenylate cyclase)
- syntaxin binding
- binding protein
- cytoplasmic domain
- protein homodimerization
- Protein kinase C conserved region 2 (CalB)
- transporter
- C2 domain
Pathways
Biological processes and signaling networks where the Syt6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- systemic juvenile idiopathic arthritis
- clear cell sarcoma of the kidney
- renal cancer
- soft tissue sarcoma cancer
- venous thromboembolism
regulates
- NFkB (complex)
- TRANS/SNARE
role in cell
- activation in
- exocytosis
- acrosome reaction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- perinuclear region
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- cytoplasmic face of plasma membrane
- reticular perinuclear compartment
- synaptic membrane
- trans Golgi network
- synaptic vesicles
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Syt6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion-dependent exocytosis
- acrosomal vesicle exocytosis
Cellular Component
Where in the cell the gene product is active
- exocytic vesicle
- perinuclear endoplasmic reticulum
- membrane
- cytosol
- synaptic vesicle membrane
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- protein homodimerization activity
- syntaxin binding
- calcium ion binding
- SNARE binding
- clathrin binding
- calcium-dependent phospholipid binding