Cic Gene Summary [Mouse]
Enables chromatin binding activity. Involved in several processes, including learning or memory; negative regulation of DNA-templated transcription; and social behavior. Acts upstream of or within lung alveolus development and negative regulation of transcription by RNA polymerase II. Part of protein-containing complex. Is expressed in several structures, including central nervous system; early conceptus; female reproductive system; hemolymphoid system; and urinary system. Used to study disease of mental health. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 45. Orthologous to human CIC (capicua transcriptional repressor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cic |
| Official Name | capicua transcriptional repressor [Source:MGI Symbol;Acc:MGI:1918972] |
| Ensembl ID | ENSMUSG00000005442 |
| Bio databases IDs | |
| Aliases | capicua transcriptional repressor |
| Synonyms | 1200010B10Rik, CAPICUA, capicua transcriptional repressor, Clone IMAGE 3028427, mKIAA0306, MRD45 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cic often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4819)
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- chromatin binding
- protein binding
- N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- neoplasia
- metastasis
- glioma formation
- gastric adenocarcinoma
- non-Hodgkin disease
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
role in cell
- proliferation
- survival
- expression in
- number
- binding in
- invasion by
- vemurafenib sensitivity
- trametinib sensitivity
- osimertinib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cic gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- negative regulation of transcription, DNA-dependent
- brain development
- learning
- memory
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity