Xrcc5 Gene Summary [Mouse]
Predicted to enable several functions, including ATP hydrolysis activity; U3 snoRNA binding activity; and sequence-specific DNA binding activity. Predicted to contribute to 5'-deoxyribose-5-phosphate lyase activity; DNA end binding activity; and double-stranded telomeric DNA binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; hemopoiesis; and positive regulation of neurogenesis. Located in cytoplasm and nucleus. Is expressed in central nervous system; nasal epithelium; and thymus primordium. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; multiple myeloma; and rectum cancer. Orthologous to human XRCC5 (X-ray repair cross complementing 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Xrcc5 |
| Official Name | X-ray repair complementing defective repair in Chinese hamster cells 5 [Source:MGI Symbol;Acc:MGI:104517] |
| Ensembl ID | ENSMUSG00000026187 |
| Bio databases IDs | |
| Aliases | X-ray repair complementing defective repair in Chinese hamster cells 5 |
| Synonyms | CTC85, CTCBF, KARP-1, KU80, Ku86, KUB2, KU (p70/p80) subunit, Kup80, NFIV, X-ray repair complementing defective repair in Chinese hamster cells 5, X-ray repair cross complementing 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Xrcc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ku N-terminal vWA domain
- Ku70/Ku80 C-terminal arm
- ubiquitin protein ligase binding
- Ku70/Ku80 beta-barrel domain
- nucleic acid binding
- nuclear localization sequence
- Ku C terminal domain like
- enzyme
- protein binding
- DNA dependent ATPase
- enzyme activator activity
- sequence-specific DNA binding
- ATPase
- carbon-oxygen lyase
- DNA end binding
- telomeric DNA binding
- DNA helicase
- RNA binding
- binding protein
- KU
- double-stranded telomeric DNA binding
- double-stranded DNA binding
- vWFA
- snoRNA binding
Pathways
Biological processes and signaling networks where the Xrcc5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-Hodgkin disease
- head and neck cancer
- cancer
- tumorigenesis
- proportional dwarfism
- growth failure
- gastrointestinal neoplasia
- T-cell non-Hodgkin disease
- T cell cancer
- lymphomagenesis
role in cell
- expression in
- damage in
- accumulation in
- cell viability
- phosphorylation in
- apoptosis
- proliferation
- number
- growth
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- pre-ribosome
- secretory granule lumen
- Cytoplasm
- Extracellular Space
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
- nuclear envelope
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Xrcc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neurogenesis
- response to xenobiotic stimulus
- double-strand break repair via nonhomologous end joining
- double-strand break repair
- regulation of smooth muscle cell proliferation
- cellular hyperosmotic salinity response
- negative regulation of transcription, DNA-dependent
- cellular response to fatty acid
- activation of innate immune response
- DNA duplex unwinding
- regulation of telomere maintenance
- small-subunit processome assembly
- recombinational repair
- DNA recombination
- telomere maintenance
- hemopoietic stem cell differentiation
- response to DNA damage stimulus
- positive regulation of telomerase activity
- cellular response to gamma radiation
- cellular response to X-ray
- positive regulation of catalytic activity
- positive regulation of protein kinase activity
- innate immune response
- protein localization to chromosome, telomeric region
- positive regulation of telomere maintenance via telomerase
- hemopoietic stem cell proliferation
- positive regulation of neurogenesis
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- DNA-dependent protein kinase complex
- nonhomologous end joining complex
- Ku70:Ku80 complex
- extracellular region
- nucleolus
- plasma membrane
- nuclear telomere cap complex
- nucleoplasm
- chromosome, telomeric region
- nucleus
- DNA-dependent protein kinase-DNA ligase 4 complex
- membrane
- protein-DNA complex
- cytosol
- secretory granule lumen
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA-dependent ATPase activity
- DNA end binding
- double-stranded DNA binding
- double-stranded telomeric DNA binding
- transcription regulatory region sequence-specific DNA binding
- enzyme activator activity
- damaged DNA binding
- DNA binding
- ATP binding
- DNA helicase activity
- RNA binding
- protein binding
- ubiquitin protein ligase binding
- 5'-deoxyribose-5-phosphate lyase activity
- telomeric DNA binding
- U3 snoRNA binding