Tlx3 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Acts upstream of or within several processes, including nervous system development; regulation of respiratory gaseous exchange by nervous system process; and respiratory gaseous exchange by respiratory system. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; ganglia; genitourinary system; and sensory organ. Used to study congenital central hypoventilation syndrome. Orthologous to human TLX3 (T cell leukemia homeobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tlx3 |
| Official Name | T cell leukemia, homeobox 3 [Source:MGI Symbol;Acc:MGI:1351209] |
| Ensembl ID | ENSMUSG00000040610 |
| Bio databases IDs | |
| Aliases | T cell leukemia, homeobox 3 |
| Synonyms | HOX11L2, RGD1564190, RNX, T cell leukaemia homeobox 3, T-cell leukaemia, homeobox 3, T cell leukemia homeobox 3, T-cell leukemia, homeobox 3, Tlx1l2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tlx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cyanosis
- dyspnea
- apnea
- T acute lymphoblastic leukemia
- respiratory failure
- tachypnea
role in cell
- differentiation
- migration
- abnormal morphology
- formation
- development
- specification
- innervation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tlx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- GABAergic neuron differentiation
- neuron migration
- central nervous system development
- neuron fate specification
- negative regulation of neuron differentiation
- organ development
- regulation of respiratory gaseous exchange by neurological system process
- respiratory gaseous exchange
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity