Mybbp1a Gene Summary [Mouse]
Enables E-box binding activity and transcription corepressor activity. Involved in circadian regulation of gene expression and negative regulation of DNA-templated transcription. Acts upstream of or within respiratory electron transport chain. Located in cytoplasm and nucleolus. Part of NLS-dependent protein nuclear import complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and limb. Orthologous to human MYBBP1A (MYB binding protein 1a). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mybbp1a |
| Official Name | MYB binding protein (P160) 1a [Source:MGI Symbol;Acc:MGI:106181] |
| Ensembl ID | ENSMUSG00000040463 |
| Bio databases IDs | |
| Aliases | MYB binding protein (P160) 1a |
| Synonyms | DBP, MBB1A, MYB binding protein 1a, MYB binding protein (P160) 1a, P160, p160MBP, P160 myb-bin, p67MBP, PAP2, Pol5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mybbp1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosome receptor lysine/proline rich region
- transcription regulator
- zinc ion binding
- RCSD region
- double-stranded DNA binding
- nucleic acid binding
- transcription co-repressor
- protein binding
- sequence-specific DNA binding
- DNA polymerase phi
Pathways
Biological processes and signaling networks where the Mybbp1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
role in cell
- apoptosis
- accumulation in
- binding in
- growth
- proliferation
- expression in
- processing in
- acetylation in
- progression
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- intracellular membrane-bounded organelle
- Cytoplasm
- cellular membrane
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mybbp1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- respiratory electron transport chain
- regulation of transcription, DNA-dependent
- ribosome biogenesis
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase III promoter
- cellular response to glucose starvation
- positive regulation of transcription from RNA polymerase I promoter
- circadian regulation of gene expression
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- signal transduction by p53 class mediator resulting in induction of apoptosis
- osteoblast differentiation
- positive regulation of anoikis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- NLS-dependent protein nuclear import complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- transcription corepressor activity
- sequence-specific DNA binding
- E-box binding