Pan2 Gene Summary [Mouse]
Predicted to enable 3'-5'-RNA exonuclease activity. Predicted to contribute to poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within nuclear-transcribed mRNA catabolic process. Located in P-body. Is expressed in 1-cell stage embryo; 2-cell stage embryo; 4-cell stage embryo; primary oocyte; and secondary oocyte. Orthologous to human PAN2 (poly(A) specific ribonuclease subunit PAN2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pan2 |
| Official Name | PAN2 poly(A) specific ribonuclease subunit [Source:MGI Symbol;Acc:MGI:1918984] |
| Ensembl ID | ENSMUSG00000005682 |
| Bio databases IDs | |
| Aliases | PAN2 poly(A) specific ribonuclease subunit |
| Synonyms | 1200014O24RIK, KIAA0710, mKIAA0710, PAN2 poly(A) specific ribonuclease subunit, poly(A) specific ribonuclease subunit PAN2, USP52 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pan2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-5' exoribonuclease
- poly(A)-specific ribonuclease
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- exonuclease
- peptidase
- EXOIII
- Ubiquitin carboxyl-terminal hydrolase
- WD40
- protein binding
- Peptidase_C19
Pathways
Biological processes and signaling networks where the Pan2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pan2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cytoplasmic mRNA processing body assembly
- mRNA processing
- nuclear-transcribed mRNA poly(A) tail shortening
Cellular Component
Where in the cell the gene product is active
- nucleus
- PAN complex
- cytosol
- cytoplasmic mRNA processing body
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- poly(A)-specific ribonuclease activity
- nucleic acid binding
- 3'-5'-exoribonuclease activity
- protein binding
- metal ion binding