Rpl22 Gene Summary [Mouse]
Enables heparin binding activity. A structural constituent of ribosome. Involved in translation at presynapse. Acts upstream of or within alpha-beta T cell differentiation. Part of cytosolic large ribosomal subunit. Is active in glutamatergic synapse; presynapse; and ribosome. Is expressed in lung. Orthologous to human RPL22 (ribosomal protein L22). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Rpl22 |
| Official Name | ribosomal protein L22 [Source:MGI Symbol;Acc:MGI:99262] |
| Ensembl ID | ENSMUSG00000028936 |
| Bio databases IDs | |
| Aliases | ribosomal protein L22 |
| Synonyms | 2700038K18Rik, EAP, eL22, HBP15, HBP15/L22, L22, Ribosomal protein L22 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- Ribosomal L22e protein family
- protein binding
- heparin binding
- identical protein binding
- translation regulator
- RNA binding
Pathways
Biological processes and signaling networks where the Rpl22 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma
- lung adenocarcinoma formation
- uterine corpus endometrioid carcinoma
- epithelial uterine cancer
- uterine corpus cancer
- endometrioid cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- renal clear cell adenocarcinoma
role in cell
- phosphorylation in
- expression in
- differentiation
- synthesis in
- development
- adherence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- presynaptic regions
- ribosome
- Nucleus
- cytosol
- nucleoli
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- alpha-beta T cell differentiation
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- focal adhesion
- cytosolic ribosome
- cytoplasm
- cytosol
- cytosolic large ribosomal subunit
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- structural constituent of ribosome
- heparin binding