Rps17 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in erythrocyte homeostasis; rRNA processing; and ribosomal small subunit biogenesis. Predicted to act upstream of or within translation. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in cerebral cortex ventricular layer and retina. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 4. Orthologous to human RPS17 (ribosomal protein S17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Rps17 |
| Official Name | ribosomal protein S17 [Source:MGI Symbol;Acc:MGI:1309526] |
| Ensembl ID | ENSMUSG00000061787 |
| Bio databases IDs | |
| Aliases | ribosomal protein S17 |
| Synonyms | DBA4, eS17, ribosomal protein S17, RPS17L, RPS17L1, RPS17L2, S17 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rps17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosomal S17
- structural constituent of ribosome
Pathways
Biological processes and signaling networks where the Rps17 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lichen planus
- diamond-blackfan anemia type 4
- aortic valve calcification
- Diamond-Blackfan anemia
regulates
- RNR
role in cell
- cell death
- translation in
- homeostasis
- nuclear export in
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- pre-ribosome
- ribosome
- cytosol
- nucleoplasm
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rps17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- erythrocyte homeostasis
- cytoplasmic translation
- ribosomal small subunit biogenesis
- rRNA processing
- translational initiation
- translation
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- focal adhesion
- cytosolic ribosome
- cytosolic small ribosomal subunit
- cytoplasm
- membrane
- cytosol
- synapse
- nucleolus
- ribosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- structural constituent of ribosome