Stat2 Gene Summary [Mouse]
Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; identical protein binding activity; and ubiquitin-like protein ligase binding activity. Involved in negative regulation of type I interferon-mediated signaling pathway and type I interferon-mediated signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Used to study Zika fever. Human ortholog(s) of this gene implicated in Zika fever; immunodeficiency 44; and neutropenia. Orthologous to human STAT2 (signal transducer and activator of transcription 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Stat2 |
| Official Name | signal transducer and activator of transcription 2 [Source:MGI Symbol;Acc:MGI:103039] |
| Ensembl ID | ENSMUSG00000040033 |
| Bio databases IDs | |
| Aliases | signal transducer and activator of transcription 2 |
| Synonyms | 1600010G07Rik, IMD44, ISGF-3, P113, PTORCH3, signal transducer and activator of transcription 2, STAT113 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stat2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Signal transducer and activator of transcription 2 C terminal
- transcription regulator
- DNA binding domain
- STAT protein, DNA binding domain
- nuclear localization sequence
- transcription activation domain
- enzyme binding
- coiled-coil domain
- protein binding
- PYTK motif
- identical protein binding
- STAT protein, all-alpha domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- STAT_CCD
- Src homology 2 (SH2) domain
- transcription factor activity
- CBP binding domain
- DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
- STAT protein, protein interaction domain
Pathways
Biological processes and signaling networks where the Stat2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Dendritic Cell Maturation
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Interferon Signaling
- JAK/Stat Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- Tec Kinase Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- Huntington disease
- insulin-dependent diabetes mellitus
- immunodeficiency 44
- psoriatic arthritis
- pseudo-TORCH syndrome type 3
- psoriasis
- T-cell non-Hodgkin disease
- Sjogren syndrome keratoconjunctivitis sicca
- neutropenia
role in cell
- phosphorylation in
- recruitment in
- apoptosis
- expression in
- proliferation
- survival
- activation in
- production in
- colony formation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Plasma Membrane
- Golgi Apparatus
- cytosol
- nucleoplasm
- chromatin
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stat2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein phosphorylation
- negative regulation of type I interferon-mediated signaling pathway
- defense response to virus
- regulation of mitochondrial fission
- defense response
- positive regulation of transcription from RNA polymerase II promoter
- response to peptide hormone stimulus
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
- JAK-STAT cascade
- type I interferon-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- ISGF3 complex
- cytosol
- chromatin
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- small conjugating protein ligase binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity