Neu1 Gene Summary [Mouse]
Enables exo-alpha-sialidase activity. Predicted to be involved in several processes, including ganglioside catabolic process; positive regulation of neuron projection development; and regulation of myoblast proliferation. Located in lysosome. Is expressed in alimentary system; brain; intestine; midgut; and midgut loop. Used to study glycoproteinosis. Human ortholog(s) of this gene implicated in mucolipidosis. Orthologous to human NEU1 (neuraminidase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Neu1 |
| Official Name | neuraminidase 1 [Source:MGI Symbol;Acc:MGI:97305] |
| Ensembl ID | ENSMUSG00000007038 |
| Bio databases IDs | |
| Aliases | neuraminidase 1 |
| Synonyms | Aglp, Apl, BAT7, G9, lysosomal sialidase, Map-2, NANH, NEU, neuraminidase 1, SIAL1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Neu1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-sialidase
- sialidases/neuraminidases
- Exo-alpha-sialidase
- enzyme
- protein binding
- BNR repeat-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atherosclerosis
- schizophrenia
- epithelial cancer
- type II sialidosis
- small cell lung cancer
- type I sialidosis
- sialidosis
- epithelial basal cell carcinoma
- small cell lung carcinoma
- breast cancer
role in cell
- expression in
- proliferation
- activation in
- quantity
- apoptosis
- cell viability
- growth
- number
- migration
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- intracellular membrane-bounded organelle
- secretory granule lumen
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- Plasma Membrane
- lysosome
- cell-cell contacts
- lysosome membrane
- lysosomal compartment
- perikaryon
- plasma
- detergent-soluble fraction
- late endosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Neu1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligosaccharide catabolic process
- ganglioside catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- specific granule lumen
- intracellular membrane-bounded organelle
- membrane
- cell junction
- lysosomal lumen
- extracellular region
- lysosomal membrane
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- alpha-sialidase activity
- exo-alpha-(2->6)-sialidase activity
- exo-alpha-(2->8)-sialidase activity
- protein binding
- exo-alpha-sialidase activity
- exo-alpha-(2->3)-sialidase activity