Stx1a

Enables SNARE binding activity and calcium channel inhibitor activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of synaptic vesicle priming; and signal release. Acts upstream of or within calcium-ion regulated exocytosis. Located in several cellular components, including axon; nuclear membrane; and secretory vesicle. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. Is expressed in several structures, including adrenal gland; male reproductive gland or organ; nervous system; retina; and skeletal muscle. Used to study disease of mental health. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease and Hirschsprung's disease. Orthologous to human STX1A (syntaxin 1A). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stx1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Stx1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Stx1a gene, providing context for its role in the cell.