Sytl4 Gene Summary [Mouse]
Enables neurexin family protein binding activity and phospholipid binding activity. Acts upstream of or within exocytosis and negative regulation of insulin secretion. Located in plasma membrane and secretory granule. Is expressed in diencephalon lateral wall ventricular layer; endocrine gland; foregut-midgut junction; and paravertebral ganglion. Orthologous to human SYTL4 (synaptotagmin like 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sytl4 |
| Official Name | synaptotagmin-like 4 [Source:MGI Symbol;Acc:MGI:1351606] |
| Ensembl ID | ENSMUSG00000031255 |
| Bio databases IDs | |
| Aliases | synaptotagmin-like 4 |
| Synonyms | Exophilin 2, Gph, Granuphilin, granuphilin-a, SLP4, slp4-a, synaptotagmin-like 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sytl4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- linker domain
- protein binding
- Slp homology domain
- FYVE domain like superfamily
- Rab binding domain
- Protein present in Fab1, YOTB, Vac1, and EEA1
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- neurexin binding
- PHD finger superfamily
- zinc finger domain
- Protein kinase C conserved region 2 (CalB)
- transporter
- C2 domain
- Rab27 binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
role in cell
- accumulation in
- abnormal morphology
- distribution
- docking
- exocytosis by
- clustering
- localization
- repair
- docking in
- repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- cellular membrane
- Plasma Membrane
- endosomes
- cytoplasmic face of plasma membrane
- apical membrane
- alpha granules
- insulin secretory granules
- neurites
- dense-core vesicles
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sytl4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome localization
- insulin secretion
- plasma membrane repair
- multivesicular body sorting pathway
- negative regulation of insulin secretion
- positive regulation of protein secretion
- intracellular protein transport
- exocytosis
- positive regulation of exocytosis
Cellular Component
Where in the cell the gene product is active
- exocytic vesicle
- platelet alpha granule membrane
- transport vesicle membrane
- endosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- neurexin family protein binding
- small GTPase binding
- phospholipid binding