Taf1 Gene Summary [Mouse]
Enables DNA binding activity; histone acetyltransferase activity; and promoter-specific chromatin binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; mRNA transcription by RNA polymerase II; and positive regulation of transcription initiation by RNA polymerase II. Located in pronucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in X-linked dystonia-parkinsonism and syndromic X-linked intellectual disability. Orthologous to several human genes including TAF1 (TATA-box binding protein associated factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Taf1 |
| Official Name | TATA-box binding protein associated factor 1 [Source:MGI Symbol;Acc:MGI:1336878] |
| Ensembl ID | ENSMUSG00000031314 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 1 |
| Synonyms | B430306D02RIK, BA2R, CCG1, CCGS, DYT3, DYT3/TAF1, KAT4, LOC100287968, LOC100291704, LOC102556339, MRXS33, NSCL2, N-TAF1, OF, P250, RGD1562050, TAF130/250, TAF250, TAF2A, TAF(II)250, TAFII-250, TATA-box binding protein associated factor 1, XDP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Taf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc knuckle
- TATA box-binding protein binding
- histone acetyltransferase domain
- protein serine/threonine kinase
- transcription regulator
- protein kinase
- protein binding activity, bridging
- transcription factor binding
- chromatin binding
- general RNA polymerase II transcription factor
- Bromodomain
- TATA-binding protein binding
- HMG-like domain
- N-terminal kinase domain
- histone binding
- histone acetyltransferase
- ligand-dependent nuclear receptor interactor
- E1 domain
- nucleic acid binding
- protein binding
- p53 binding
- sequence-specific DNA binding
- acidic domain
- Protein of unknown function (DUF3591)
- DNA binding
- kinase
- kinase domain
- ubiquitin conjugating enzyme
- Swi4 homology domain
- Rap binding domain
- double-stranded DNA binding
- E2 domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Taf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung squamous cell carcinoma
- renal clear cell adenocarcinoma
- renal clear cell cancer
- syndromic X-linked mental retardation type 33
- hereditary disorder
- mental retardation
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
regulates
- TP53
- AR
- Cyclin a
- reporter gene
- synthetic promoter
- Pd1
- DNA promoter
- DNA endogenous promoter
- peptide
- RNA polymerase II
role in cell
- response by
- missegregation in
- missegregation
- polyubiquitination in
- homologous recombination repair in
- cell cycle progression
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nucleoli
- pronucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Taf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein binding
- transcription initiation from RNA polymerase I promoter
- positive regulation of transcription initiation from RNA polymerase II promoter
- transcription from RNA polymerase II promoter
- protein autophosphorylation
- protein phosphorylation
- positive regulation of transcription from RNA polymerase II promoter
- transcription initiation from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- midbrain development
- chromatin remodeling
- RNA polymerase II transcriptional preinitiation complex assembly
- cellular response to UV
- cellular response to ATP
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- mRNA transcription from RNA polymerase II promoter
- protein polyubiquitination
- response to DNA damage stimulus
- ubiquitin-dependent protein catabolic process
- negative regulation of gene expression
- positive regulation of androgen receptor activity
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein stabilization
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- transcription factor TFIID complex
- nucleolus
- chromatin
- MLL1 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- RNA polymerase II core promoter sequence-specific DNA binding
- sequence-specific DNA binding
- protein kinase activity
- protein serine/threonine kinase activity
- ATP binding
- histone acetyltransferase activity
- p53 binding
- protein binding
- protein heterodimerization activity
- general RNA polymerase II transcription factor activity
- core RNA polymerase I binding transcription factor activity
- histone acetyl-lysine binding
- RNA polymerase II basal transcription factor binding
- TBP-class protein binding
- kinase activity