Acacb Gene Summary [Mouse]
Enables acetyl-CoA carboxylase activity. Involved in several processes, including malonyl-CoA biosynthetic process; positive regulation of heart growth; and regulation of small molecule metabolic process. Acts upstream of or within fatty acid biosynthetic process and response to caloric restriction. Located in mitochondrion. Is active in mitochondrial outer membrane. Is expressed in axial skeleton; cranium; and liver. Orthologous to human ACACB (acetyl-CoA carboxylase beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acacb |
| Official Name | acetyl-Coenzyme A carboxylase beta [Source:MGI Symbol;Acc:MGI:2140940] |
| Ensembl ID | ENSMUSG00000042010 |
| Bio databases IDs | |
| Aliases | acetyl-Coenzyme A carboxylase beta |
| Synonyms | ACACbeta, ACC2, ACCB, ACC-beta, ACC-β, acetyl-CoA carboxylase beta, acetyl-CoA carboxylase β, acetyl-Coenzyme A carboxylase beta, acetyl-Coenzyme A carboxylase β, AW743042, C87246, HACC275, LOC283445 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acacb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- biotin binding
- ATP-grasp domain
- Biotin carboxylase C-terminal domain
- enzyme
- protein binding
- identical protein binding
- Acetyl-CoA carboxylase, central region
- Biotinyl_lipoyl_domains
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- Biotin carboxylase, N-terminal domain
- biotin carboxylase
- Biotin-requiring enzyme
- Carboxyl transferase domain
- acetyl-CoA carboxylase
- PRK12999
Pathways
Biological processes and signaling networks where the Acacb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- obesity
- pervasive developmental disorder
- cervical carcinoma
- epithelial uterine cancer
- cervical cancer
- insulin resistance
- ductal breast carcinoma
- ductal breast cancer
role in cell
- growth in
- lipolysis in
- generation in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial outer membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acacb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- malonyl-CoA biosynthetic process
- positive regulation of heart growth
- pentose-phosphate shunt
- acetyl-CoA metabolic process
- lactic acid secretion
- response to nutrient
- glucose import
- response to organic cyclic compound
- response to xenobiotic stimulus
- fatty acid biosynthetic process
- negative regulation of gene expression
- tricarboxylic acid metabolic process
- protein homotetramerization
- regulation of glucose metabolic process
- negative regulation of fatty acid beta-oxidation
- fatty acid oxidation
- energy homeostasis
- positive regulation of lipid storage
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial fatty acid beta-oxidation multienzyme complex
- mitochondrion
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- metal ion binding
- acetyl-CoA carboxylase activity
- biotin binding