Derl3 Gene Summary [Mouse]
Predicted to enable signal recognition particle binding activity. Predicted to be involved in several processes, including ERAD pathway; negative regulation of retrograde protein transport, ER to cytosol; and protein N-linked glycosylation via asparagine. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; genitourinary system; long bone epiphyseal plate; sensory organ; and spleen. Orthologous to human DERL3 (derlin 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Derl3 |
| Official Name | Der1-like domain family, member 3 [Source:MGI Symbol;Acc:MGI:1917627] |
| Ensembl ID | ENSMUSG00000009092 |
| Bio databases IDs | |
| Aliases | Der1-like domain family, member 3 |
| Synonyms | 1810006I20Rik, 1810063P04Rik, C22orf14, Der1-like domain family, member 3, derlin-3, IZP6, LLN2, LOC103694875, LOC686906 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Derl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signal recognition particle binding
- binding protein
- protein binding
- Rhomboid family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- lung adenocarcinoma
- lung adenocarcinoma formation
- dextran sodium sulfate-induced colitis
role in cell
- endoplasmic reticulum stress response
- N-glycosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Derl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endoplasmic reticulum unfolded protein response
- protein N-linked glycosylation via asparagine
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signal recognition particle binding