DERL3 Gene Summary [Human]
The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Details
| Type | Processed Transcript |
| Official Symbol | DERL3 |
| Official Name | derlin 3 [Source:HGNC Symbol;Acc:HGNC:14236] |
| Ensembl ID | ENSG00000099958 |
| Bio databases IDs | |
| Aliases | derlin 3 |
| Synonyms | 1810006I20Rik, 1810063P04Rik, C22orf14, Der1-like domain family, member 3, derlin-3, IZP6, LLN2, LOC103694875, LOC686906 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DERL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signal recognition particle binding
- binding protein
- protein binding
- Rhomboid family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- lung adenocarcinoma
- lung adenocarcinoma formation
- dextran sodium sulfate-induced colitis
role in cell
- endoplasmic reticulum stress response
- N-glycosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DERL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- endoplasmic reticulum unfolded protein response
- protein N-linked glycosylation via asparagine
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signal recognition particle binding