Plcg2

Enables phosphatidylinositol-4,5-bisphosphate phospholipase C activity and phosphorylation-dependent protein binding activity. Involved in several processes, including immune response-activating signaling pathway; positive regulation of cytokine production; and response to fungus. Acts upstream of or within several processes, including activation of store-operated calcium channel activity; follicular B cell differentiation; and regulation of calcium-mediated signaling. Located in cytosol and membrane raft. Is expressed in several structures, including alimentary system; bone; cardiovascular system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. Orthologous to human PLCG2 (phospholipase C gamma 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plcg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Plcg2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Plcg2 gene, providing context for its role in the cell.