Sugp1 Gene Summary [Mouse]
Enables mRNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to be part of spliceosomal complex. Predicted to be active in nucleoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SUGP1 (SURP and G-patch domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sugp1 |
| Official Name | SURP and G patch domain containing 1 [Source:MGI Symbol;Acc:MGI:1917866] |
| Ensembl ID | ENSMUSG00000011306 |
| Bio databases IDs | |
| Aliases | SURP and G patch domain containing 1 |
| Synonyms | 5730496N02Rik, F23858, RBP, SF4, SURP and G-patch domain containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sugp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-patch domain
- mRNA binding
- Surp module
- protein binding
- Suppressor-of-White-APricot splicing regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver neoplasia
- nonalcoholic fatty liver disease
- non-insulin-dependent diabetes mellitus
- alcoholic cirrhosis
- migraines
- diabetes mellitus
- cirrhosis
- hypercholesterolemia
- nonalcoholic steatohepatitis
- coronary artery disease
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sugp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding