Dap3 Gene Summary [Mouse]
Predicted to be a structural constituent of ribosome. Acts upstream of or within apoptotic mitochondrial changes. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; gonad; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in Perrault syndrome 7. Orthologous to human DAP3 (death associated protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dap3 |
| Official Name | death associated protein 3 [Source:MGI Symbol;Acc:MGI:1929538] |
| Ensembl ID | ENSMUSG00000068921 |
| Bio databases IDs | |
| Aliases | death associated protein 3 |
| Synonyms | 4921514D13Rik, bMRP-10, Ced3, death associated protein 3, IONIZING RADIATION RESISTANCE CONFERRING, MRP-S29, mS29, S29mt |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dap3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mitochondrial presequence
- N-terminal helicase domain of the DEAD-box helicase superfamily
- protein binding
- basic helix loop helix/Per Arnt Sim domain
- GTP binding motif, P-loop
Pathways
Biological processes and signaling networks where the Dap3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- adenoma formation
- epithelial cancer
- inflammatory bowel disease
- gonadal dysgenesis with auditory dysfunction, autosomal recessive inheritance
- Perrault syndrome type 1
- breast carcinoma
- thyroid cancer
- major depression
- prostatic carcinoma
role in cell
- growth
- apoptosis
- morphology
- cell death
- phosphorylation in
- anoikis
- fragmentation
- splicing regulation in
- autophagy in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dap3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic signaling pathway
- mitochondrial translation
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial small ribosomal subunit
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- RNA binding
- structural constituent of ribosome