Pkd2l2 Gene Summary [Mouse]
Predicted to enable calcium channel activity. Predicted to be involved in detection of mechanical stimulus. Predicted to be active in membrane. Is expressed in several structures, including cochlea; pancreas; reproductive system; spleen; and stomach. Orthologous to human PKD2L2 (polycystin 2 like 2, transient receptor potential cation channel). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Pkd2l2 |
| Official Name | polycystic kidney disease 2-like 2 [Source:MGI Symbol;Acc:MGI:1858231] |
| Ensembl ID | ENSMUSG00000014503 |
| Bio databases IDs | |
| Aliases | polycystic kidney disease 2-like 2 |
| Synonyms | polycystic kidney disease 2-like 2, polycystin 2 like 2, transient receptor potential cation channel, TRPP5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pkd2l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ion transport protein
- Polycystin domain
- ion channel
- Polycystin cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pkd2l2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of mechanical stimulus
- calcium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- calcium channel activity
- calcium ion binding