PKD2L2 Gene Summary [Human]
Predicted to enable calcium channel activity. Predicted to be involved in detection of mechanical stimulus. Predicted to be integral component of membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PKD2L2 |
| Official Name | polycystin 2 like 2, transient receptor potential cation channel [Source:HGNC Symbol;Acc:HGNC:9012] |
| Ensembl ID | ENSG00000078795 |
| Bio databases IDs | |
| Aliases | polycystin 2 like 2, transient receptor potential cation channel, transient receptor potential cation channel subfamily P member 5 |
| Synonyms | polycystic kidney disease 2-like 2, polycystin 2 like 2, transient receptor potential cation channel, TRPP5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PKD2L2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ion transport protein
- Polycystin domain
- ion channel
- Polycystin cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PKD2L2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of mechanical stimulus
- calcium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- calcium channel activity
- calcium ion binding