Trpm7 Gene Summary [Mouse]
Enables cytoskeletal protein binding activity; metal ion transmembrane transporter activity; and protein kinase activity. Involved in intracellular magnesium ion homeostasis; metal ion transport; and protein homotetramerization. Acts upstream of or within several processes, including actomyosin structure organization; calcium-dependent cell-matrix adhesion; and protein autophosphorylation. Located in several cellular components, including cytoplasmic vesicle; nucleus; and ruffle. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and skin. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trpm7 |
| Official Name | transient receptor potential cation channel, subfamily M, member 7 [Source:MGI Symbol;Acc:MGI:1929996] |
| Ensembl ID | ENSMUSG00000027365 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel, subfamily M, member 7 |
| Synonyms | 2310022G15Rik, 4833414K03Rik, 5033407O22Rik, ALSPDC, CHAK, CHAK1, LOC499884, Ltpr7, LTRPC7, transient receptor potential cation channel subfamily M member 7, transient receptor potential cation channel, subfamily M, member 7, TRP-PLIK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trpm7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha kinase family
- protein serine/threonine kinase
- protein kinase
- tetramerization domain of TRPM
- Ion transport protein
- calcium channel
- Alpha-kinase family
- protein binding
- zinc ion transporter
- kinase
- myosin binding
- kinase domain
- SLOG in TRPM
- phospholipase C interacting kinase domain
- actin binding
- magnesium ion transporter
- cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- amyotrophic lateral sclerosis
- neonatal necrotizing enterocolitis
- pancreatic cancer
- hypomagnesemia with secondary hypocalcemia
- cardiac hypertrophy
- acne
- amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam
- high-fat diet-induced obesity
- tremor
role in cell
- expression in
- degradation in
- activation in
- growth
- cell death
- phosphorylation in
- ubiquitination in
- apoptosis
- cell viability
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- axon component
- ruffle
- cellular membrane
- Nucleus
- cytoplasmic vesicles
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trpm7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- necroptosis
- actomyosin structure organization
- protein tetramerization
- calcium ion transport
- calcium ion transmembrane transport
- calcium-dependent cell-matrix adhesion
- cation homeostasis
Cellular Component
Where in the cell the gene product is active
- ruffle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- actin binding
- metal ion binding
- calcium channel activity
- myosin binding
- protein serine/threonine kinase activity