Tsen15 Gene Summary [Mouse]
Predicted to enable nucleic acid binding activity. Predicted to be involved in mRNA processing and tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to be located in nucleolus. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2F. Orthologous to human TSEN15 (tRNA splicing endonuclease subunit 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tsen15 |
| Official Name | tRNA splicing endonuclease subunit 15 [Source:MGI Symbol;Acc:MGI:1913887] |
| Ensembl ID | ENSMUSG00000014980 |
| Bio databases IDs | |
| Aliases | tRNA splicing endonuclease subunit 15 |
| Synonyms | 5730449L18RIK, C1orf19, D6Mgi32, PCH2F, RGD1308584, SEN15, tRNA splicing endonuclease subunit 15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tsen15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA-intron endonuclease
- Sen15 protein
- enzyme
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tsen15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA splicing, via endonucleolytic cleavage and ligation
- mRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding