Cnksr3 Gene Summary [Mouse]
Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of peptidyl-serine phosphorylation; and positive regulation of sodium ion transport. Acts upstream of or within positive regulation of sodium ion transmembrane transporter activity. Predicted to be located in apical plasma membrane and cytoplasm. Is expressed in dentate gyrus subgranular zone. Orthologous to human CNKSR3 (CNKSR family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cnksr3 |
| Official Name | Cnksr family member 3 [Source:MGI Symbol;Acc:MGI:2674130] |
| Ensembl ID | ENSMUSG00000015202 |
| Bio databases IDs | |
| Aliases | Cnksr family member 3 |
| Synonyms | 6820402C05, CNK3, CNK3/IPCEF1, CNKSR family member 3, MAGI1, Prp4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cnksr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Connector enhancer of kinase suppressor of ras
- Domain present in PSD-95, Dlg, and ZO-1/2
- Sterile alpha motif
- SAM (Sterile alpha motif )
- SAM domain (Sterile alpha motif)
- canonical PDZ domain
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
- Connector enhancer of kinase suppressor of ras 2/3 domain
Pathways
Biological processes and signaling networks where the Cnksr3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- small cell lung cancer
- Parkinson disease
- idiopathic femoral head osteonecrosis
regulated by
- lipopolysaccharide
- gentamicin
- Eber2
- E4
- NR3C2
- aldosterone
- IgG
- ovalbumin
- E6
- mir-30 (includes others)
regulates
- DLL1
- Na+
- MAP2K1/2
- peptide
role in cell
- phosphorylation in
- transcellular transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell-cell contacts
- apical membrane
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cnksr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of ERK1 and ERK2 cascade
- positive regulation of sodium ion transport
- negative regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding