Nisch Gene Summary [Mouse]
Enables integrin binding activity. Acts upstream of or within Rac protein signal transduction; actin cytoskeleton organization; and negative regulation of cell migration. Located in cytosol. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Used to study otitis media. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nisch |
| Official Name | nischarin [Source:MGI Symbol;Acc:MGI:1928323] |
| Ensembl ID | ENSMUSG00000021910 |
| Bio databases IDs | |
| Aliases | nischarin |
| Synonyms | 1200007D05Rik, 3202002H23Rik, edsn, hIRAS, I-1, I1R, I1 receptor, Imidazoline-1 Receptor, IR1, IRAS, Nischarin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nisch often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- integrin binding
- Leucine rich repeat
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- Leucine Rich repeats (2 copies)
- identical protein binding
- acidic domain
- PX domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- cancer
- diabetic nephropathy
- obesity
- schizophrenia
- central obesity
- metabolic syndrome X
- diverticular disease
- malaria
role in cell
- organization
- binding in
- phosphorylation in
- migration
- formation
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- soluble fraction
- detergent-soluble membrane fractions
- filopodia-like projection
- microtubule cytoskeleton
- intracellular membrane-bounded organelle
- Cytoplasm
- perinuclear region
- cytoplasmic bridges
- cytosol
- nucleoplasm
- perikaryon
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nisch gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Rac protein signal transduction
- outer dynein arm assembly
- apoptotic process
- actin cytoskeleton organization
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- early endosome
- intercellular bridge
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- recycling endosome
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- phosphatidylinositol binding
- integrin binding
- alpha-tubulin binding
- dynein heavy chain binding