Dip2b Gene Summary [Mouse]
Enables alpha-tubulin binding activity. Involved in negative regulation of axon extension and positive regulation of peptidyl-lysine acetylation. Located in axon; dendrite; and perikaryon. Is expressed in several structures, including central nervous system; gut; liver; retina; and spleen. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder type FRA12A. Orthologous to human DIP2B (disco interacting protein 2 homolog B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dip2b |
| Official Name | disco interacting protein 2 homolog B [Source:MGI Symbol;Acc:MGI:2145977] |
| Ensembl ID | ENSMUSG00000023026 |
| Bio databases IDs | |
| Aliases | disco interacting protein 2 homolog B |
| Synonyms | 4932422C22, disco-interacting protein 2 homolog B, FLJ34278, mKIAA1463, RGD1305671 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dip2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AMP-binding enzyme
- DMAP1-binding Domain
- alpha-tubulin binding
- Adenylate forming domain, Class I superfamily
- amino acid adenylation domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- cutaneous melanoma
- epithelial cancer
- low-grade glioma
- pancreatic adenocarcinoma
- squamous cell lung cancer
- acute myeloid leukemia
- lung squamous cell carcinoma
- esophageal carcinoma
- esophageal carcinoma formation
regulated by
- paraquat
- STAT5B
- pyridaben
- maneb
role in cell
- apoptosis
- proliferation
- migration
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dip2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of axon extension
- positive regulation of peptidyl-lysine acetylation
- nervous system development
Cellular Component
Where in the cell the gene product is active
- nucleus
- dendrite
- extracellular vesicular exosome
- cytoplasm
- membrane
- perikaryon
- axon
Molecular Function
What the gene product does at the molecular level
- alpha-tubulin binding