Lage3 Gene Summary [Mouse]
Predicted to be involved in tRNA threonylcarbamoyladenosine metabolic process. Predicted to be located in cytoplasm and nuclear body. Predicted to be part of EKC/KEOPS complex. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 2. Orthologous to human LAGE3 (L antigen family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lage3 |
| Official Name | L antigen family, member 3 [Source:MGI Symbol;Acc:MGI:1913442] |
| Ensembl ID | ENSMUSG00000015289 |
| Bio databases IDs | |
| Aliases | L antigen family, member 3 |
| Synonyms | 1110049G11Rik, CVG5, DXS9879E, DXS9951E, ESO3, GAMOS2, ITBA2, L antigen family member 3, L antigen family, member 3, Pcc1, RGD1562476 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lage3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transcription factor Pcc1
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lage3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA processing
- threonylcarbamoyladenosine metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- EKC/KEOPS complex
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding