Ubr5 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in negative regulation of smoothened signaling pathway and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Acts upstream of or within negative regulation of interleukin-17 production and regulation of protein stability. Predicted to be located in several cellular components, including chromatin; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in cranial ganglion; nervous system; sensory organ; submandibular gland primordium; and vibrissa. Human ortholog(s) of this gene implicated in breast cancer (multiple) and carcinoma (multiple). Orthologous to human UBR5 (ubiquitin protein ligase E3 component n-recognin 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ubr5 |
| Official Name | ubiquitin protein ligase E3 component n-recognin 5 [Source:MGI Symbol;Acc:MGI:1918040] |
| Ensembl ID | ENSMUSG00000037487 |
| Bio databases IDs | |
| Aliases | ubiquitin protein ligase E3 component n-recognin 5 |
| Synonyms | DD5, EDD, EDD1, HYD, LOC102551120, Rat100, ubiquitin protein ligase E3 component n-recognin 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ubr5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative zinc finger in N-recognin (UBR box)
- UBA domain-like superfamily
- LXXLL motif
- ubiquitin protein ligase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- ubiquitin binding
- central domain
- protein domain specific binding
- enzyme
- protein binding
- Poly-adenylate binding protein, unique domain
- C-terminal domain of Poly(A)-binding protein
- Putative zinc finger in N-recognin
- HECTc
- UBR-box
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glioma formation
- gastroesophageal reflux
- glioma
- insomnia
- Hutchinson-Gilford progeria syndrome
- gastric carcinoma
- gastric epithelial cancer
- postmenopausal osteoporosis
- infection by Influenza A virus subtype H1N1
role in cell
- proliferation
- activation in
- phosphorylation in
- expression in
- cell viability
- growth
- invasion by
- apoptosis
- migration
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- pH resistant lipid raft fraction
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ubr5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- protein K11-linked ubiquitination
- positive regulation of protein import into nucleus
- cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- protein polyubiquitination
- positive regulation of canonical Wnt receptor signaling pathway
- response to DNA damage stimulus
- negative regulation of smoothened signaling pathway
- proteasomal ubiquitin-dependent protein catabolic process
- protein K29-linked ubiquitination
- nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of gene expression
- progesterone receptor signaling pathway
- negative regulation of extent of heterochromatin assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- cytosol
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- RNA binding
- ubiquitin binding
- ubiquitin-ubiquitin ligase activity