Rufy1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity; protein domain specific binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within protein transport; regulation of endocytosis; and small GTPase-mediated signal transduction. Located in cytoplasm. Is expressed in brain; genitourinary system; heart; liver; and lung. Orthologous to human RUFY1 (RUN and FYVE domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rufy1 |
| Official Name | RUN and FYVE domain containing 1 [Source:MGI Symbol;Acc:MGI:2429762] |
| Ensembl ID | ENSMUSG00000020375 |
| Bio databases IDs | |
| Aliases | RUN and FYVE domain containing 1 |
| Synonyms | 3000002E04Rik, FLJ22251, RABIP4, RUN and FYVE domain containing 1, ZFYVE12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rufy1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FYVE zinc finger
- domain involved in Ras-like GTPase signaling
- SH2-domain binding
- protein binding activity, bridging
- leucine zipper domain
- coiled-coil domain
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- identical protein binding
- SH3-domain binding
- FYVE domain like superfamily
- Protein present in Fab1, YOTB, Vac1, and EEA1
- Family with sequence similarity 184, A and B
- PHD finger superfamily
- RUN domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- intracellular membrane-bounded organelle
- endosomes
- cytosol
- endosomal membrane
- nuclear speckles
- early endosomes
- cytoplasmic vesicles
- endocytotic vesicle
- sorting endosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rufy1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- small GTPase mediated signal transduction
- protein transport
- regulation of endocytosis
- early endosome to Golgi transport
- endosomal vesicle fusion
- endocytosis
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- endosome
- cytoplasm
- nuclear speck
- intracellular membrane-bounded organelle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- lipid binding
- SH3 domain binding
- SH2 domain binding
- protein binding, bridging