Atf6b Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to contribute to DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in endoplasmic reticulum unfolded protein response; negative regulation of ATF6-mediated unfolded protein response; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within mitotic chromosome condensation and negative regulation of gene expression. Predicted to be located in several cellular components, including early endosome; endoplasmic reticulum membrane; and nuclear lumen. Predicted to be part of RNA polymerase II transcription regulator complex and protein-DNA complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human ATF6B (activating transcription factor 6 beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atf6b |
| Official Name | activating transcription factor 6 beta [Source:MGI Symbol;Acc:MGI:105121] |
| Ensembl ID | ENSMUSG00000015461 |
| Bio databases IDs | |
| Aliases | activating transcription factor 6 beta |
| Synonyms | AA617266, activating transcription factor 6 beta, activating transcription factor 6 β, ATF6beta, ATF6B isoform 1, Atf6 β, CREBL1, CREB-RP, G13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atf6b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- nucleic acid binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- basic helix-loop-helix-leucine zipper domain
- double-stranded DNA binding
- lumenal domain
- transmembrane domain
- bZIP
- Cell division protein ZapB
- transcription factor activity
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Atf6b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inguinal hernia
- neuroticism
- chronic obstructive pulmonary disease
- sarcoidosis
- multiple sclerosis
- Takayasu arteritis
- irritable bowel syndrome
- postmenopausal osteoporosis
role in cell
- expression in
- proliferation
- degradation in
- transcription in
- stress recovery
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- endomembrane system
- Cytoplasm
- intracellular space
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- microtubule organizing centers
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- chromosome
- nucleoplasm
- nucleoli
- nuclear matrix
- early endosomes
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atf6b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- endoplasmic reticulum unfolded protein response
- positive regulation of transcription from RNA polymerase II promoter
- response to endoplasmic reticulum stress
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- protein-DNA complex
- cytosol
- Golgi membrane
- Golgi apparatus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity