Cmah Gene Summary [Mouse]
Enables CMP-N-acetylneuraminate monooxygenase activity. Acts upstream of or within CMP-N-acetylneuraminate metabolic process. Located in cytoplasm. Orthologous to human CMAHP (cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cmah |
| Official Name | cytidine monophospho-N-acetylneuraminic acid hydroxylase [Source:MGI Symbol;Acc:MGI:103227] |
| Ensembl ID | ENSMUSG00000016756 |
| Bio databases IDs | |
| Aliases | cytidine monophospho-N-acetylneuraminic acid hydroxylase |
| Synonyms | cytidine monophospho-N-acetylneuraminic acid hydroxylase, Neuraminic Acid Hydroxylase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cmah often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rieske
- CMP-N-acetylneuraminate monooxygenase
- enzyme
Pathways
Biological processes and signaling networks where the Cmah gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- IFNG
- interleukin
- Lt iib b
- GM2 N-glycolylneuraminic acid ganglioside
- N-glycolylneuraminic acid
- IgG1
- CMP-sialic acid
phenotypes
- abnormal B cell physiology
- abnormal T cell physiology
- abnormal humoral immune response
- abnormal inner ear morphology
- abnormal interleukin secretion
- abnormal organ of Corti morphology
- abnormal semicircular canal morphology
- abnormal sensorimotor gating
- abnormal startle reflex
- cochlear outer hair cell degeneration
- decreased interferon-gamma secretion
- impaired coordination
- impaired hearing
- impaired wound healing
- increased B cell proliferation
- increased IgG1 level
- increased vertical activity
- premature death
role in cell
- function
- binding
- proliferation
- synthesis in
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- cellular membrane
- Nucleus
- Endoplasmic Reticulum