Mpp2 Gene Summary [Mouse]
Enables transmembrane transporter binding activity. A structural constituent of postsynaptic density. Involved in excitatory postsynaptic potential and long-term synaptic potentiation. Located in dendrite membrane; dendritic shaft; and dendritic spine. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut gland; respiratory system; and retina. Orthologous to human MPP2 (MAGUK p55 scaffold protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mpp2 |
| Official Name | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) [Source:MGI Symbol;Acc:MGI:1858257] |
| Ensembl ID | ENSMUSG00000017314 |
| Bio databases IDs | |
| Aliases | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) |
| Synonyms | D11Bwg0652e, DKFZp761D0712, DLG2, Dlgh2, MAGUK p55 scaffold protein 2, membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2), Pals4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mpp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- protein binding
- PDZ domain
- PDZ-domain binding
- Src Homology 3 domain superfamily
- L27 domain
- kinase
- guanylate kinase
- NK
- guanylate kinase-like domain
- ion channel binding
- structural molecule
- cpPDZ_Deg_HtrA-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon epithelial cancer
- sensory neuropathy
- tinnitus
- colon adenocarcinoma
- Vogt-Koyanagi-Harada disease
- vascular leak syndrome
- metabolic syndrome X
- infection by HIV-1
role in cell
- expression in
- epithelial barrier function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cytoskeleton
- cell surface
- synaptic membrane
- dendritic spines
- synapse
- dendrites
- postsynaptic density
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mpp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- protein homooligomerization
- long-term synaptic potentiation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite membrane
- cell-cell junction
- cytoskeleton
- cytoplasm
- dendritic shaft
- dendritic spine
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding