Pgs1 Gene Summary [Mouse]
Predicted to enable CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity. Predicted to be involved in cardiolipin biosynthetic process and diacylglycerol metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; lung; nervous system; and skin. Orthologous to human PGS1 (phosphatidylglycerophosphate synthase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pgs1 |
| Official Name | phosphatidylglycerophosphate synthase 1 [Source:MGI Symbol;Acc:MGI:1921701] |
| Ensembl ID | ENSMUSG00000017715 |
| Bio databases IDs | |
| Aliases | phosphatidylglycerophosphate synthase 1 |
| Synonyms | 2610019F11Rik, 4933424M23Rik, Pgp synthase, phosphatidylglycerophosphate synthase 1, RGD1305052, SAF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pgs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium ion binding
- CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
- enzyme
- helix-loop-helix domain
- Catalytic domain of phospholipase D superfamily proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- lymphomagenesis
- primary central nervous system lymphoma
- lipoprotein lipase deficiency
- metabolic syndrome X
- Parkinson disease
- primary cancer
- central nervous system cancer
regulates
- cardiolipin
- BCL2L1
role in cell
- morphology
- fragmentation in
- fragmentation
- tubulation in
- partitioning in
- cellular respiration in
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pgs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylglycerol biosynthetic process
- cardiolipin biosynthetic process
- diacylglycerol metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- endoplasmic reticulum
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calcium ion binding
- CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity