Pdlim1 Gene Summary [Mouse]
Enables transcription coactivator activity. Acts upstream of or within regulation of transcription by RNA polymerase II. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; heart; and sensory organ. Orthologous to human PDLIM1 (PDZ and LIM domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdlim1 |
| Official Name | PDZ and LIM domain 1 (elfin) [Source:MGI Symbol;Acc:MGI:1860611] |
| Ensembl ID | ENSMUSG00000055044 |
| Bio databases IDs | |
| Aliases | PDZ and LIM domain 1 (elfin) |
| Synonyms | CLIM1, CLP-36, hCLIM1, HEL-S-112, mClim1, PDLI1, PDZ and LIM domain 1, PDZ and LIM domain 1 (elfin) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pdlim1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4749)
- Domain present in PSD-95, Dlg, and ZO-1/2
- transcription regulator
- transcription co-activator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- actin binding
- canonical PDZ domain
- central domain
- ZASP-like motif
- protein binding
- PDZ domain
- Serine Proline motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- organismal death
- focal segmental glomerulosclerosis
- alcoholic liver disease
- membranous glomerulonephritis
- metastasis
role in cell
- activation in
- proliferation
- expression in
- phosphorylation in
- migration
- formation
- binding in
- invasion by
- force generation by
- tubulation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- actin cytoskeleton
- Plasma Membrane
- actin bundles
- Z line
- cortical actin filaments
- microfilaments
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pdlim1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- heart development
- response to hypoxia
- positive regulation of transcription, DNA-dependent
- maintenance of cell polarity
- muscle structure development
- establishment or maintenance of actin cytoskeleton polarity
- stress fiber assembly
- fibroblast migration
- actin cytoskeleton organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- Z disc
- transcription factor complex
- adherens junction
- cytoskeleton
- focal adhesion
- cytoplasm
- stress fiber
- filamentous actin
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- actin binding
- metal ion binding
- muscle alpha-actinin binding