Wfdc2 Gene Summary [Mouse]
Predicted to enable aspartic-type endopeptidase inhibitor activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; liver; and retina. Orthologous to human WFDC2 (WAP four-disulfide core domain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Wfdc2 |
| Official Name | WAP four-disulfide core domain 2 [Source:MGI Symbol;Acc:MGI:1914951] |
| Ensembl ID | ENSMUSG00000017723 |
| Bio databases IDs | |
| Aliases | WAP four-disulfide core domain 2 |
| Synonyms | 1600023A02RIK, BENP, dJ461P17.6, EDDM4, HE4, MAJOR EPIDIDYMIS SPECIFIC protein E4, RE4, WAP5, WAP four-disulfide core domain 2, WFDC2 isoform 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wfdc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WAP
- endopeptidase inhibitor
- WAP-type (Whey Acidic Protein) 'four-disulfide core'
- aspartic protease inhibitor
- serine protease inhibitor activity
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- prostate cancer
- diabetic nephropathy
- serous ovarian adenocarcinoma
- serous ovarian cancer
- survival
- bronchiectasis and nasal polyposis
- ovarian cancer
- uterine endometrioid carcinoma
- epithelial uterine cancer
role in cell
- phosphorylation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wfdc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- innate immune response
- proteolysis
- antibacterial humoral response
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding
- endopeptidase inhibitor activity
- cysteine-type endopeptidase inhibitor activity
- aspartic-type endopeptidase inhibitor activity