Nbr1 Gene Summary [Mouse]
Enables mitogen-activated protein kinase binding activity. Involved in negative regulation of osteoblast differentiation; regulation of bone mineralization; and regulation of stress-activated MAPK cascade. Located in late endosome; mitochondrial intermembrane space; and phagophore assembly site. Colocalizes with autophagosome. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system; and liver and biliary system. Orthologous to human NBR1 (NBR1 autophagy cargo receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nbr1 |
| Official Name | NBR1, autophagy cargo receptor [Source:MGI Symbol;Acc:MGI:108498] |
| Ensembl ID | ENSMUSG00000017119 |
| Bio databases IDs | |
| Aliases | NBR1, autophagy cargo receptor |
| Synonyms | 1A1-3B, CA125, IAI3B, IAI.3B, M17S2, MIG19, mKIAA0049, NBR1 autophagy cargo receptor, NBR1, autophagy cargo receptor, RGD1311421 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nbr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- ZZ
- LC3-interacting region
- protein kinase binding
- ubiquitin binding
- NBR1_like
- protein binding
- zinc binding domain
- PB1
- Phox and Bem1 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypersensitivity pneumonitis
- Nonaka myopathy
role in cell
- expression in
- phosphorylation in
- activation in
- activity
- senescence
- degradation
- differentiation
- accumulation in
- priming
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- Mitochondria
- cytosol
- mitochondrial intermembrane space
- peroxisome membrane
- nucleoplasm
- nuclear bodies
- autophagic vacuoles
- late endosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nbr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of stress-activated MAPK cascade
- macroautophagy
- regulation of bone mineralization
- negative regulation of osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- nuclear body
- pre-autophagosomal structure
- late endosome
- receptor complex
- autophagic vacuole
- nucleoplasm
- lysosome
- peroxisomal membrane
- mitochondrial intermembrane space
- intracellular membrane-bounded organelle
- mitochondrion
- membrane
- cytosol
- M band
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- ubiquitin binding
- mitogen-activated protein kinase binding