Vmp1 Gene Summary [Mouse]
Predicted to enable phospholipid scramblase activity. Involved in autophagy and lipoprotein transport. Acts upstream of or within embryo implantation. Located in phagophore assembly site. Orthologous to human VMP1 (vacuole membrane protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vmp1 |
| Official Name | vacuole membrane protein 1 [Source:MGI Symbol;Acc:MGI:1923159] |
| Ensembl ID | ENSMUSG00000018171 |
| Bio databases IDs | |
| Aliases | vacuole membrane protein 1 |
| Synonyms | 3110098I04RIK, 4930579A11RIK, DKFZp566I133, EPG3, mir-21a, ni-2, TANGO5, TMEM49, vacuole membrane protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vmp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid scramblase
- SNARE associated Golgi protein
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- glioblastoma
- glioblastoma cancer
- major depression
- iron deficiency anemia
- abdominal aortic aneurysm
- idiopathic dilated cardiomyopathy
- breast carcinoma
- calcium overload
- chronic lymphocytic leukemia
regulates
- Ca2+
- NFkB (complex)
- PI3K (complex)
- LIPOPROTEIN
role in cell
- apoptosis
- activation in
- growth
- assembly
- generation in
- generation
- autophagy by
- docking
- endoplasmic reticulum stress response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nucleoli
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vmp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- autophagy
- Golgi organization
- autophagic vacuole docking
- phospholipid scrambling
- cell junction assembly
- embryo implantation
- lipoprotein transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- pre-autophagosomal structure
- membrane
- endomembrane system
- endoplasmic reticulum
- nucleolus
- plasma membrane
- autophagic vacuole membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phospholipid scramblase activity