Dnase1l1 Gene Summary [Mouse]
Predicted to enable DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in DNA catabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. Orthologous to human DNASE1L1 (deoxyribonuclease 1 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnase1l1 |
| Official Name | deoxyribonuclease 1-like 1 [Source:MGI Symbol;Acc:MGI:109628] |
| Ensembl ID | ENSMUSG00000019088 |
| Bio databases IDs | |
| Aliases | deoxyribonuclease 1-like 1 |
| Synonyms | 2310005K03RIK, deoxyribonuclease 1-like 1, DNAS1L1, DNASE1LL, DNASEX, DNL1L, Dnl1ll, ENDONUCLEASE, G4.8, XIB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnase1l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNase
- 5' phosphomonoester producing endodeoxyribonuclease
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- Endonuclease/Exonuclease/phosphatase family
- enzyme
- protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- secretory granule lumen
- cell surface
- Extracellular Space
- cellular membrane
- sarcoplasmic reticulum
- Golgi Apparatus
- Endoplasmic Reticulum
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnase1l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA catabolic process
- DNA metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- specific granule lumen
- endoplasmic reticulum
- extracellular region
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- deoxyribonuclease activity
- deoxyribonuclease I activity