Rpl23 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in several processes, including cellular response to actinomycin D; protein stabilization; and regulation of macromolecule metabolic process. Predicted to act upstream of with a positive effect on G1 to G0 transition and regulation of G1 to G0 transition. Predicted to act upstream of or within translation. Located in cytoplasm and nucleolus. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in several structures, including central nervous system; retina; and uterus. Orthologous to human RPL23 (ribosomal protein L23). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl23 |
| Official Name | ribosomal protein L23 [Source:MGI Symbol;Acc:MGI:1929455] |
| Ensembl ID | ENSMUSG00000071415 |
| Bio databases IDs | |
| Aliases | ribosomal protein L23 |
| Synonyms | 2810009A01Rik, L17a, L23, ribosomal protein L23, RL23a, rpL17, Rpl17a, uL14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- structural constituent of ribosome
- Ribosomal protein L14p/L23e
- enzyme inhibitor activity
- transcription factor binding
- protein binding
- enzyme regulator activity
Pathways
Biological processes and signaling networks where the Rpl23 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- metabolic syndrome X
- lymphomagenesis
- lymphoma
- chronic kidney disease
- recurrent implantation failure
role in cell
- expression in
- proliferation
- response by
- autophagy in
- G1/S phase transition
- translation in
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- ribosome
- cytosol
- nucleoplasm
- nucleoli
- synapse
- postsynaptic density
- exosomes
- free polysome fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to actinomycin D
- cytoplasmic translation
- positive regulation of gene expression
- positive regulation of cell proliferation
- G1 to G0 transition
- protein-DNA complex disassembly
- protein stabilization
- translation
- ribosomal protein import into nucleus
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- cytosolic large ribosomal subunit
- synapse
- nucleolus
- ribosome
- nucleoplasm
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- ubiquitin protein ligase binding
- structural constituent of ribosome
- LSU rRNA binding
- transcription coactivator binding